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Image Search Results
Journal: Molecular Brain
Article Title: Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats
doi: 10.1186/s13041-018-0351-1
Figure Lengend Snippet: RvD2 exerted rescue effects on MCAO/R-induced neuron and BMVEC death. Apoptotic cell death was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Sections were labeled by TUNEL (green) to detect apoptotic neurons (red) ( a ) and brain microvascular endothelial cells (BMVECs) (red) ( c ) and counterstained with DAPI (blue) to detect nuclei. Arrows point to TUNEL-positive cells. The percentage of TUNEL-positive brain cells was calculated ( b and d ). Scale bar = 64 μm (A) and 24 μm ( c ). Data are expressed as mean ± SEM, n = 6. ** P < 0.01 vs. sham group, & P < 0.05, N.S. = no significant differences. e Fluoro-Jade B (FJB) staining was used to detect necrosis. Scale bar = 64 μm. The number of FJB-positive brain cells was calculated ( f ). Data are expressed as mean ± SEM, n = 6. ** P < 0.01 vs. sham group, & P < 0.05, N.S. = no significant differences
Article Snippet: The
Techniques: TUNEL Assay, Staining, Labeling
Journal: Small (Weinheim an Der Bergstrasse, Germany)
Article Title: Passively Targeted Curcumin-Loaded PEGylated PLGA Nanocapsules for Colon Cancer Therapy In Vivo
doi: 10.1002/smll.201403799
Figure Lengend Snippet: Histological examination of major organs and TUNEL staining of tumors after multiple administrations via tail vein. A) Haematoxylin and eosin (H&E) stained sections of kidney, liver, spleen, and lung in CT26 tumor-bearing Balb/c mice. Mice were injected i.v. a total of four injections on day 11, 15, 19, and 24 d post-tumor inoculation at drug dose of 16 mg curcumin per kg or with saline. No histological abnormalities were found in major organs. B) H&E and TUNEL stained tumor sections examined after multiple administrations of NC. Larger apoptotic (white arrows) and necrotic (black arrows) areas were detected in NC injected animals compared to control animals. TUNEL and DAPI were counterstained to identify apoptotic (green) cells from the total cell population (blue nuclei) in the bottom row. Scale bar 100 μm for H&E and 500 μm for TUNEL.
Article Snippet:
Techniques: TUNEL Assay, Staining, Injection, Saline, Control